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Gait alteration is frequent in MS and limitation in walking ability is a major concern in MS patients. The development of wearable device offers the opportunity to collect data during daily activity including walking.
Umanit and LMJ (Nantes university) has developed a device call eMSgait to assess walking ability in MS patients individuals (eg MS patients). This device consists in a commercialized IMU sensor (MetaMotionR Sensor, Mbientilab) worn at the right hip, a smartphone app and dedicated algorithm/mathematical model to extract raw sensor data and calculate individual gait pattern (IGP). This IGP consists of a curve, based on quaternion and representing the rotation recorded by the IMU during an average gait cycle. Pursue first pilot work assessing information from IGP on gait alteration in MS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| eMSGait | Record of IGP using IMU sensor (Metamotion R mbientlab) during T25FW. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wearable sensor | Other | IMU sensor (as part of eMSGait device) worn at the hip during T25FW |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation with disability | Correlation of gait measures (mean amplitude of walking cycles (m), mean duration of walking cycles (s), Stance swing phase ratio) obtained during a walk of 25 feet with Expanded Disability Status Scale (EDSS). EDSS is an ordinal scale measuring disability and ranging from 0 (normal examination) to 10 (death due to MS) in a 0,5-point increments from score 1. | One time point per patient (inclusion) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation with neurological function | Pyramidal, cerebellar and sensory functions are assessed with Kurtzke functional system scores which are based on neurological examination. Scores of the Pyramidal and sensory systems range from 0 (normal) to 6 . Cerebellar system scores range from 0 (normal) to 6. Cerebellar system scores range from 0 (normal) to 5 | One time point per patient (inclusion) |
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Inclusion Criteria:
Exclusion Criteria:
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MS patients cohort followed at Nantes university hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Nantes | Loire-Atlantique | 44093 | France |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| Correlation with gait speed | Timed 25-Foot Walk (T25FW). T25FW measures the time needed to complete a 25-foot walk. Two trials are averaged | One time point per patient (inclusion) |
| Correlation with lateralization | Lower limb lateralization (right vs left) | One time point per patient (inclusion) |
| Correlation with disability location | Upper, lower limb, trunk MS symptoms location | One time point per patient (inclusion) |
| Correlation with MS symptoms severity | MS symptoms severity quote as none, mild moderate severe | One time point per patient (inclusion) |
| Reliability of sensor measures | Gait parameters record during a 25-foot walk repeated twice at 5 min apart. | At the inclusion |
| Developement of dedicated algorithm to improve signal processing from IMU. | Number of detected gait cycles during a foot walk. | Day 1 |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |