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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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The refeeding syndrome has been reported without any evidence of prolopnged semistarvation, thus being different from the traditional disease.
The investigators wanted to investigate, if sodium infusions could be part of the explanation.
Background: Refeeding syndrome is conventionally connected to start of feeding after prolonged periods of semi-starvation and adaption. However, it is also described in acutely ill patients and in ICU patients without a history of adaption, but sometimes only defined as a drop in p-phosphate without clinical manifestations. The investigators hypothesize, that a positive sodium balance could induce the refeeding-like syndrome (RLS).
Method: Consecutive patients for acute, abdominal surgery were included and observed until discharge or up to seven days postoperatively with daily sodium and phosphate balance measurements.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| acute abdominal surgery | Procedure | Acute surgery for acute abdominal disease |
| Measure | Description | Time Frame |
|---|---|---|
| sodium balance | correlation between sodium balance and occurrence of the refeeding syndrome | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| plasma phosphate | correlation between sodium balance and change in plasma phosphate | 7 days |
| urinary excretion of phosphate | correletion between sodium balance and urinary excretion of phosphate |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive, adult patients for acute, abdominal surgery were asked top be included and observed until discharge or up to seven days postoperatively with daily sodium and phosphate balance measurements.
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| Name | Affiliation | Role |
|---|---|---|
| jens R Andersen | University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Herlev University Hospital | Herlev | 2730 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42036070 | Derived | Mikkelsen KK, Djurhuus M, Ritz C, Lin VA, Boel T, Voldby AW, Andersen JR. Associations between positive sodium balance and a refeeding-like syndrome following acute abdominal surgery: A prospective cohort study. Clin Nutr ESPEN. 2026 Jun;73:103297. doi: 10.1016/j.clnesp.2026.103297. Epub 2026 Apr 24. |
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| ID | Term |
|---|---|
| D055677 | Refeeding Syndrome |
| D000006 | Abdomen, Acute |
| ID | Term |
|---|---|
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D015746 | Abdominal Pain |
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| 7 days |
| phosphate balance | correlation between decline in plasma phosphate and urinary excretion of phosphate | 7 days |
| D010146 |
| Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012817 | Signs and Symptoms, Digestive |