The Effect of Dilution and Prolonged Injection Time on Dexamethasone-induced Perineal Irritation

The Effect of Dilution With Glucose and Prolonged Injection Time on Dexamethasone-induced Perineal Irritation

The purpose of this study is to investigate the efficacy of dilution with glucose and prolonged injection time on dexamethasone 21-phosphate induced perineal irritation (include pian and pruritus).

Dexamethasone is a synthetic glucocorticoid, which may cause perineal irritation when given intravenously. The major clinical manifestations are pruritus and pain，and the incidence vary between 38%-71%. Some patients undergo spontaneous remission, while others develop into severe pain or pruritus. In clinical practice, dexamethasone is always diluted with glucose in many cases, but diluted dexamethasone in relieving dexamethasone induced perineal irritation has not been studied yet. The aim of this study was to investigate the efficacy of dilution with glucose on dexamethasone induced perineal irritation.

Inclusion Criteria:

• Aged 18-65 years
• ASA physical status I-II

Exclusion Criteria:

• On regular use of analgesic
• Contraindication or allergy to steroid or glucose
• Drug or alcohol abuse
• Diagnosed with paresthesia or mental diseases
• Communication disorders
• Pregnancy or nursing