Effect of Dexamethasone on Postoperative Inflammatory Factors

Effect of Dexamethasone on Postoperative Inflammatory Factors in Elderly Patients Undergoing Lunmbar Spine Surgery

This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.

A total of 100 patients undergoing posterior lumbar disc fusion were randomly divided into control group (group C,n=50) and dexamethasone group (group D,n=50). Group D was given 0.15mg/kg dexamethasone (2ml) intravenously after anesthesia induction. Group C was also intravenously injected with 2ml normal saline after anesthesia induction.On this basis, monitor the main results and secondary results

Inclusion Criteria:

• Adult patients ≥65years of age
• American Society of Anesthesiologists (ASA) physical status 2-4
• Elective or expedited non-cardiac surgery of at least 2 hours dura- tion under general anaesthesia
• Requiring a hospital stay of at least one postoperative night
• A surgical skin incision >5 cm in length or multiple incisions with a total incision length of >5 cm

Exclusion Criteria:·

• Poorly controlled diabetes (HbA1c>9.0%)
• Endovascular procedure with a small (<5 cm length) skin incision Ophthalmic surgery
• Planned dexamethasone (or other corticosteroid) therapy (eg, history of intractable PONV, maxillofacial surgery, intracranial neurosurgery)
• Recent (<2 weeks since end of treatment) infective episode requir- ing treatment with antibiotics
• Chronic antibiotic therapy (eg, for bronchiectasis, cystic fibrosis etc)