150 GT3 or GT6 CHC patients with or without compensated cirrhosis will be recruited from five centers in China including G3a 50, G3b 50, G6 50 respectively. GT3a and GT6 CHC with or without compensated patients will be administered one pill of Epclusa each day for 12 weeks, and GT3b patients will be administered Epclusa each plus Ribavirin for 12 weeks.

This is a Prospective, observational, multi-center, real-world study to investigate real world effectiveness and safety of SOF/VEL±RBV in Chinese patients infected by HCV GT-3 and 6. 150 GT3 or GT6 CHC patients with or without compensated cirrhosis will be recruited from five centers in China including G3a 50, G3b 50, G6 50 respectively. GT3a and GT6 CHC with or without compensated cirrhosis will be administered one pill of Epclusa each day for 12 weeks, and GT3b patients will be administered one pill of Epclusa each plus Ribavirin for 12 weeks.Demographic, clinical, adverse event and virological data were be collected throughout treatment and post-treatment follow-up.

Inclusion Criteria:

• HCV RNA ≥ 15 IU/Ml at Screening
• HCV genotype 3a ,3b and 6
• Hepatitis C without decompensated cirrhosis of the liver

Exclusion Criteria:

• Patients failed to previous NS5A-containing DAAs therapy
• Decompensated cirrhosis
• HCC
• Infection with hepatitis B virus (HBV) or human immunodeficiency virus (HIV).

The groups or cohorts will be selected from people who was diagnosed with hepatitis c at the hospital.