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Prematurity is associated with an increased risk of developing cardiovascular and metabolic disturbances in adulthood.
It has been demonstrated that the body composition of children born prematurely is different from that of children born under term with a deficit in fat free mass.
It can thus be wondered if this excessive adiposity does or does not predict the risk of insulin resistance in adulthood.
Children born prematurely, with a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol, and now aged between 8 and 14 years, will be included in the INFANTPOD protocol.
Analysis of body composition, insulin resistance, renal function, pulse wave velocity, eating behaviour and of physical activity will be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children born prematurely included in the EPIPOD protocol and now in the peripubertal period | Experimental | At inclusion in the INFANTPOD study :
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| clinical and biological measurements and questionnaires | Other | Blood and urinary samples collection for evaluation of insulin resistance and of renal function analysis. Assessment of body composition by BOP-POD and by impedancemetry. Assessment of pulse wave by popmetre. Assessment of physical activity by accelerometer and by questionnaire Questionnaires for analysis of eating behaviour |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin resistance as measured by the Triglyceride-Glucose Index | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin resistance as measured by the Homeostasis Model Assessment - Insulin Resistance index | 1 day | |
| Body composition (percentage of fat versus fat free mass) by BOP-POD and by impedancemetry (biodyXpert) for assessment of body composition variations between peripubertal period and neonatal period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anne FRONDAS, Doctor | Contact | +33 2 40 08 34 83 | anne.frondas@chu-nantes.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes University Hospital | Recruiting | Nantes | 44600 | France |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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|
| 1 day |
| creatinine clearance | 1 day |
| Eating behaviour using standardized questionnaire named Child Eating Behaviour questionnaire | 1 day |
| Eating behaviour using standardized french questionnaire named "QCAJE Questionnaire Comportement Alimentaire du Jeune Enfant" | 1 day |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |