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Investigate the compliance of oral anticoagulants in Chinese NVAF patients and find out the causes, so as to provide basis for formulating effective measures to improve the compliance of oral anticoagulants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dabigatran group | NVAF patients who taking dabigatran capsule 110mg,bid during 2016.2-2021.1,the duration of continuous medication was more than 3 months.PDC value and MMAS-8 scale were used to evaluate the compliance of patients with dabigatran. |
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| Rivaroxaban group | NVAF patients who taking rivaroxaban tablet 15mg,bid during 2016.2-2021.1,the duration of continuous medication was more than 3 months.PDC value and mmas-8 scale were used to evaluate the compliance of patients with dabigatran. PDC value and mmas-8 scale were used to evaluate the compliance of patients with rivaroxaban. |
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| wafarin group | NVAF patients who taking wafarin tablet during 2016.2-2021.1,the duration of continuous medication was more than 3 months, the dosage is adjusted according to INR. MMAS-8 scale was used to evaluate the compliance of patients with rivaroxaban.evaluate the compliance of patients with wafarin. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| adherence | Other | PDC value and MMAS-8 scale were used to evaluate the compliance of patients with dabigatran, rivaroxaban and wafarin |
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| Measure | Description | Time Frame |
|---|---|---|
| The long-term compliance of oral anticoagulants in NVAF patients was compared among warfarin group, dabigatran group and rivaroxaban group. | In this study, the eight item Morisky medication adherence scale (MMAS-8) was used to compare the long-term compliance of patients with warfarin, dabigatran axetil and rivaroxaban. The proportion of days covered (PDC) was used to compare the long-term compliance of patients with dabigatran and rivaroxaban. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Explore the influence of different factors on patients' compliance, and to find out the factors influencing patients' long-term compliance, so as to provide basis for formulating strategies to improve patients' long-term compliance. | Data of all influencing factors included in CHA2DS2-VASc score scale, such as age hypertension,heart failure, diabetes, women and vascular diseases, as well as region, medical insurance category, education level, anticoagulant use history and HAS-BLED score |
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Inclusion Criteria:
NVAF; CHA2DS2-VASc≥2(femal≥3); After starting the medication, the duration of continuous medication was more than 3 months
Exclusion Criteria:
The patients had the records of anticoagulants in other hospitals; Patients lost to follow-up; Patients who do not need long-term anticoagulants after successful radiofrequency ablation or left atrial appendage occlusion. The follow-up time was 3 years or the following conditions occurred: the patient's condition changed and no longer used oral anticoagulants or died, the follow-up was stopped.
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Through the hospital information system (HIS), the information of patients using warfarin, dabigatran and rivaroxaban during 2016.1-2-2021.1 was retrieved
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| chang cuie, master | Contact | 15990165032 | changcuie123@163.com | |
| zhang xiaoyu, master | Contact | 18858160685 | 474430517@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| huang yuwen, master | The Second Affiliated Hospital of Medical College of Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Cuie | Hangzhou | Zhejiang | 086 | China |
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| 6 months |
| Through multivariate logistic regression analysis, to clarify the impact of various factors on long-term compliance of patients. | Univariate analysis of significant variables, further by multivariate logistic regression analysis | 6 months |