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To describe the rate of discontinuation among Non-Valvular Atrial Fibrillation (NVAF) patients who were on warfarin and have switched to the Novel oral anticoagulants(NOACs).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients naive to oral anticoagulant treatment | NVAF patients naïve to oral anticoagulant treatment (Naïve) |
| |
| patients with prior warfarin therapy | NVAF patients with prior warfarin therapy (Warfarin treated) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| apixaban | Drug |
| ||
| dabigatran |
| Measure | Description | Time Frame |
|---|---|---|
| Discontinuation rate of patients with prior warfarin use | up to 31 months | |
| Rate of major bleeding events of patients with prior warfarin use | up to 31 months | |
| Rate of hospitalization due to major bleeding events of patients with warfarin use | up to 31 months | |
| Discontinuation rate of patients who were naïve to oral anticoagulant | up to 31 months | |
| Rate of major bleeding events of patients who were naïve to oral anticoagulant | up to 31 months | |
| Rate of hospitalization due to major bleeding events of patients who were naïve to oral anticoagulant | up to 31 months |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of All-Cause Hospitalization | up to 31 months | |
| Rate of Atrial Fibrillation(AF)-Related Hospitalization | up to 31 months | |
| Rate of All-Cause Any Rehospitalization |
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Inclusion Criteria:
Exclusion Criteria:
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The initial study population will include Non-valvular atrial fibrillation (NVAF) patients who initiated warfarin or Novel oral anticoagulants (NOACs) between January 01, 2012 and August 31, 2014. The date of the first NOAC prescription claim during the enrollment period will serve as the index date. The patients who have at least 1 year of baseline data available will be included in the study.
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| Name | Affiliation | Role |
|---|---|---|
| Bristol-Myers Squibb | Bristol-Myers Squibb | Study Director |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| C522181 | apixaban |
| D000069604 | Dabigatran |
| D000069552 | Rivaroxaban |
| D014859 | Warfarin |
| ID | Term |
|---|---|
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
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| Drug |
|
| rivaroxaban | Drug |
|
| warfarin | Drug |
|
| up to 31 months |
| Rate of AF-Related Any Rehospitalization | up to 31 months |
| Rate of All-Cause Early Hospitalization | up to 31 months |
| Rate of AF-Related Early Hospitalization | up to 31 months |
| All-Cause Healthcare per patient per month (PPPM) cost | up to 31 months |
| AF-related Healthcare per patient per month (PPPM) cost | up to 31 months |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D006574 |
| Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D009025 | Morpholines |
| D010078 | Oxazines |
| D015110 | 4-Hydroxycoumarins |
| D003374 | Coumarins |
| D001578 | Benzopyrans |
| D011714 | Pyrans |