Desogestrel for the Preoperative Treatment of Endometrioma Compared With Placebo

The Use of Oral Desogestrel for the Preoperative Treatment of Endometrioma Compared With Placebo : A Randomized Controlled Trial Evaluation of the Effect on Cyst Diameter and Associated Pain

Use of the oral desogestrel compared with placebo for preoperative treatment of endometrioma in the patient who underwent to surgery in next 3 months The result will be evaluated on cyst diameter, the associated pain and side effect of the oral desogestrel.

Use of the oral desogestrel compared with placebo for preoperative treatment of endometrioma in the patient who underwent to surgery in next 3 months in Rajvithi hospital Patient will randomized in 2 group : Desogestrel and placebo After 1 months and 3 months the patient have to come to hospital to evaluate the result of study The result will be evaluated on cyst diameter, the associated pain and side effect of the oral desogestrel.

Inclusion Criteria:

• Thai female and foreigner who can understand Thai language
• Age 15-49 years
• Diagnose as endometrioma sized more than 3 cm
• Underwent to surgery in next 13 weeks

Exclusion Criteria:

• History of endometriosis
• Pregnancy woman
• Contraindication for desogestrel : History of thrombotic event, Autoimmune disease,gestational trophoblastic disease
• Ovarian endometrioma with complications : Ruptured, twisted
• Contraindications for NSAIDs : Peptic ulcer, thrombocytopenia, liver disease
• History of hormonal treatment for endometrioma : DMPA,OCP, GNRH agonist/antoginist