In this prospective longitudinal observational investigator-led single centre cohort study we will include patients undergoing cardio-CT for clinical reasons, to evaluate the role of cardio-CT terms of its diagnostic and prognostic value, as well as risk-benefit ratio.

Particular aims include:

1. To determine the prevalence of CAD for age, gender, ethnicity relative to established risk models

2. To determine associations between CAD severity and plaque type and:

   1. with traditional risk factors (arterial hypertension, diabetes, hypercholesterolemia, smoking)
   2. blood markers of increased cardiovascular risk

3. To determine predictive associations of between CAD with outcome (endpoint definitions in appendix)

4. To determine the risk-benefit ratio (number of subsequent interventions, complications, radiation exposure, late onset of cancer diseases, etc).

Particular aims include:

1. To determine the prevalence of CAD for age, gender, ethnicity relative to established risk models

2. To determine associations between CAD severity and plaque type and:

   1. with traditional risk factors (arterial hypertension, diabetes, hypercholesterolemia, smoking)
   2. blood markers of increased cardiovascular risk

3. To determine predictive associations of between CAD with outcome (endpoint definitions in appendix)

4. To determine the risk-benefit ratio (number of subsequent interventions, complications, radiation exposure, late onset of cancer diseases, etc).

Inclusion Criteria:

1. Adults (=/>18 years of age)
2. Able to provide informed consent
3. Clinical indication for cardio-CT in line with the latest clinical guidelines

Exclusion Criteria:

1. standard contraindications to CT (in line with local roles and guidelines - please see Appendix)
2. known allergy to iodinated contrast agent
3. suspected acute kidney injury
4. unstable hemodynamic status or arrhythmias
5. suspected acute coronary syndrome
6. manifest thyrotoxicosis

Adults referred to clinical cardiac computertomography imaging