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| Name | Class |
|---|---|
| Ondokuz Mayıs University | OTHER |
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The study aims to investigate the rationale for LPN in patients with high-complexity renal tumors in terms of oncologic and functional outcomes.
From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN and 265 patients to the LRN group. Propensity score matching (matched by age, gender, clinical tumor stage, tumor size, baseline renal function, comorbidities such as diabetes mellitus (DM), hypertension (HT), coronary artery disease (CAD), and final tumor pathology of RCC) was used to reduce selection bias. Functional and oncological outcomes were compared between the two groups. After propensity score analysis, 39 patients in the LRN group were matched with 39 in the LPN group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LPN group | 39 patients with high complexity renal tumors who underwent laparoscopic partial nephrectomy |
| |
| LRN group | 39 patients with high complexity renal tumors who underwent laparoscopic radical nephrectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| laparoscopic partial nephrectomy | Procedure | Nephron sparing minimally invasive surgery |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Operation time | time from onset to complete of surgery | at the end of the surgery |
| Blood loss | amount of bleeding during surgery (mL) | at the end of the surgery |
| warm ischemia time | The clamp time of the renal artery and vein which is required to complete tumor excision and renorrhaphy | at the and of the surgery |
| Postoperative complication | abnormal problmes that may be seen after surgery and require additional intervention, treatment or follow-up | up to 3 months postoperatively |
| functional outcomes | serum creatinine level (mg /dL) and estimated glomerular filtration rate (CKD Epidemiology Collaboration (CKD-EPI) equation) (mL/min/1.73 m2) | 1 year after the surgery |
| surigcal margin status | presence or absence of tumors at the surgical margin | postoperative follow-up, through study completion, an average of 1 year |
| CKD stage upgrading | evaluation of preoperative and postoperative renal functions according to chronic kidney disease stages | postoperative follow-up, through study completion, an average of 1 year |
| Oncological outomes |
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Inclusion Criteria:
Exclusion Criteria:
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From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN and 265 patients to the LRN group. Propensity score matching (matched by age, gender, clinical tumor stage, tumor size, baseline renal function, comorbidities such as diabetes mellitus (DM), hypertension (HT), coronary artery disease (CAD) and final tumor pathology of RCC) was used to reduce selection bias. Functional and oncological outcomes were compared between the two groups. After propensity score analysis, 39 patients in the LRN group were matched with 39 in the LPN group.
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| Name | Affiliation | Role |
|---|---|---|
| Ender Ozden, Prof. | Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Üroloji Anabilim dalı | Study Director |
| Saban Sarıkaya, Prof. | Ondokuz Mayıs University, Faculty of Medicine, Department of Urology | Study Chair |
| Mehmet Mercimek, MD, FEBU | Liv Hospital Samsun, Department of Urology | Principal Investigator |
| Yakup Bostancı, Prof. | Ondokuz Mayıs University, Faculty of Medicine, Department of Urology | Principal Investigator |
| Murat Gulsen, MD | Samsun Gazi State Hospital, Departmen of Urology, Samsun, Turkey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ondokuz Mayıs University, Department of Urology | Samsun | 55020 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27988238 | Result | Kim SP, Campbell SC, Gill I, Lane BR, Van Poppel H, Smaldone MC, Volpe A, Kutikov A. Collaborative Review of Risk Benefit Trade-offs Between Partial and Radical Nephrectomy in the Management of Anatomically Complex Renal Masses. Eur Urol. 2017 Jul;72(1):64-75. doi: 10.1016/j.eururo.2016.11.038. Epub 2016 Dec 14. | |
| 27614693 | Result |
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| ID | Term |
|---|---|
| D007680 | Kidney Neoplasms |
| D002292 | Carcinoma, Renal Cell |
| D009369 | Neoplasms |
| D014571 | Urologic Neoplasms |
| ID | Term |
|---|---|
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| Laparoscopic radical nephrectomy |
| Procedure |
Completely removal of kidney by using laparoscopic surgery |
|
Presence or absence of local and/or distal tumor recurrence |
| postoperative follow-up, through study completion, an average of 1 year |
| Mir MC, Derweesh I, Porpiglia F, Zargar H, Mottrie A, Autorino R. Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies. Eur Urol. 2017 Apr;71(4):606-617. doi: 10.1016/j.eururo.2016.08.060. Epub 2016 Sep 7. |
| 31677114 | Result | Yang F, Zhou Q, Xing N. Comparison of survival and renal function between partial and radical laparoscopic nephrectomy for T1b renal cell carcinoma. J Cancer Res Clin Oncol. 2020 Jan;146(1):261-272. doi: 10.1007/s00432-019-03058-z. Epub 2019 Nov 1. |
| D000091642 | Urogenital Diseases |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |