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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DTI group | the patient in this group will receive DTI evaluation |
| |
| routine group | the patient in this group will receive routine evaluation |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| diffusion tensor imaging(DTI) evaluation | Other | DTI is a new kind of MRI technique to evaluate peripheral neuropathy |
|
| Measure | Description | Time Frame |
|---|---|---|
| To assess the optimal b-value (a key parameter) for DTI in AAV associated peripheral neuropathy | b-value is a key technique parameter for DTI, which will decide the quality of DTI image | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| the association between normative diffusion value of DTI (FA and ADC value) and disease activity activity score of AAV (BVAS). | Birmingham Vasculitis Activity Score (BVAS) is a index of vasculitis disease activity, with the score range 0-63. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) are two parameters that can be read through DTI image . | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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adult AAV patients with peripheral neuropathy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| wenjia sun | Contact | 86 15869029727 | sunwinjoy@zju.edu.cn | |
| ting zhang | Contact | 86 15888819691 | zhangtingpumc@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Jing Xue | 2nd affiliated hospital of Zhejiang University, School of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd affiliated hospital of Zhejiang University, School of Medicine | Recruiting | Hangzhou | Zhejiang | 310000 | China |
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| the association between normative diffusion value of DTI (FA and ADC value) and serum biomarkers of AAV associated neuropathy | sCD163, Nfl（neurofilament light polypeptide）and OPN（osteopontin）are new biomarkers of peripheral neuropathy | 2 years |
| ID | Term |
|---|---|
| D056648 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis |
| D010523 | Peripheral Nervous System Diseases |
| ID | Term |
|---|---|
| D056647 | Systemic Vasculitis |
| D014657 | Vasculitis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D017445 | Skin Diseases, Vascular |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
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