In the fight against the epidemic, medical personnel need to wear protective equipment, such as N95 mask, face screen, goggles, latex gloves, waterproof isolation clothing, and have special requirements. Protection-related skin lesions after the use of protective equipment will affect the health and comfort of medical workers. In this study, a retrospective study was conducted on the front-line medical workers in the fight against COVID-19 using questionnaires, so as to understand the incidence, location and clinical manifestations of skin lesions caused by the use of protective equipment by medical workers. And analyze the causes of these skin damage, so as to develop the corresponding prevention and treatment countermeasures, select 170 cases that meet the research conditions, a randomized controlled experiment, divided into control group and experimental group: the control group is on the basis of three-level protection, did not use any preventive measures of health care workers. In the experimental group, skin related prevention was carried out on the basis of three-level protection. The specific interventions are as follows :(1) Focus on protecting exposed skin and making it locally dry. (2) Do a good job of facial moisturizing before work (at least 1 hour before wearing the mask), use moisturizing ointment, longer lasting and non-irritating cream or emulsion, such as vitamin E cream, Vaseline, avoid direct contact with the skin of the mask, choose the appropriate type of protective device; Reduce friction by sticking foam paste, hydrocolloid accessories, ampute and so on on good hair parts. However, it should be noted that it must be confirmed that the airtightness is good, and the primary purpose of the medical staff is to ensure the protective effect. (4) After work, avoid using irritant (such as hot water, exfoliating cream, etc.) to clean the face, and massage local skin with skin moisturizer; (5) In case of severe skin damage, treat as prescribed by the doctor; (6) After finishing the front-line work, "Questionnaire Star" was used to collect data, and all data were input into the statistical software for analysis to compare the index differences between the two groups.

Inclusion Criteria:

1. Job post: fever clinic, COVID-19 throat swab sampling site, isolation ward
2. Health care workers who have worked for 30 days or more
3. The continuous working time of tertiary protection shall be more than or equal to 4 hours
4. Signed the informed consent and volunteered to participate in the study.

Exclusion Criteria:

1. Existing long-term skin damage
2. The skin damage related to protection is too heavy to be studied