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| Name | Class |
|---|---|
| Quorn | INDUSTRY |
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Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response.
Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mycoprotein | Experimental | Bolus ingestion of mycoprotein providing 25g of protein. |
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| Pea protein | Experimental | Bolus ingestion of pea protein providing 25g of protein. |
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| Mycoprotein/pea protein dry blend | Experimental | Bolus ingestion of mycoprotein/pea protein dry blend providing 25g of protein. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bolus ingestion of protein | Dietary Supplement | Ingestion of 25g of protein |
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| Measure | Description | Time Frame |
|---|---|---|
| Muscle protein synthesis | The rate of synthesis of new muscle protein (Fractional synthetic rate %/h) | 8.5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma amino acid kinetics | The appearance of amino acids from the protein drink in the circulation. | 8.5 hours |
| Serum insulin concentrations | Basal and postprandial concentrations of serum insulin |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Exeter | Exeter | United Kingdom |
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| 8.5 hours |
| Translocation of mTOR via immunohistochemistry | Locality of mTOR within the muscle cell | 8.5 hours |
| mTOR phosphorylation via ATP kinase assay | The amount of mTOR that has been activated in the muscle cell | 8.5 hours |