Intestinal Permeability and Gastroparesis

Assessing Intestinal Barrier Function and Permeability in Patients With Gastroparesis

The purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.

Inclusion Criteria:

• Adult patients (18-75 years old).
• Men and women.
• Patients with gastroparesis.

Exclusion Criteria:

• Patients will be excluded from the study if symptoms are thought to represent an organic disorder (e.g., peptic ulcer disease, hepatitis, pancreatitis, inflammatory bowel disease, a known malignancy, radiation-induced injury, an active infection, vasculitis, celiac disease), GERD, esophagitis, eosinophilic esophagitis or H. pylori.
• Patients with uncontrolled diabetes mellitus (hemoglobin A1C > 10).
• Patients with prior surgery to the esophagus, stomach or duodenum.
• Patients taking opioids, steroids, anti-histamines, immunosuppressive agents, NSAIDs, or mast cell stabilizing agents within the prior 3 months.
• Patients currently prescribed aspirin or aspirin regimens for other clinical reasons.
• Patients with known allergies to lactulose: mannitol will be excluded.