Study withdrawn due to funding.

The purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.

Inclusion Criteria:

• Adult patients (18-75 years old).
• Men and women.
• Patients with gastroparesis.

Exclusion Criteria:

• Patients will be excluded from the study if symptoms are thought to represent an organic disorder (e.g., peptic ulcer disease, hepatitis, pancreatitis, inflammatory bowel disease, a known malignancy, radiation-induced injury, an active infection, vasculitis, celiac disease), GERD, esophagitis, eosinophilic esophagitis or H. pylori.
• Patients with uncontrolled diabetes mellitus (hemoglobin A1C > 10).
• Patients with prior surgery to the esophagus, stomach or duodenum.
• Patients taking opioids, steroids, anti-histamines, immunosuppressive agents, NSAIDs, or mast cell stabilizing agents within the prior 3 months.
• Patients currently prescribed aspirin or aspirin regimens for other clinical reasons.
• Patients with known allergies to lactulose: mannitol will be excluded.