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| Name | Class |
|---|---|
| Pamela Youde Nethersole Eastern Hospital | OTHER |
| Queen Elizabeth Hospital, Hong Kong | OTHER |
| Princess Margaret Hospital, Hong Kong | OTHER_GOV |
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It is to explore the temporal relationships between physical fitness, cognitive, psychosocial functions, and health-related quality of life (HRQoL) in COVID-19 survivors over the first 15 months; and to determine the effects of centre-based (CBR), online-based cardiopulmonary rehabilitation (OBR), and combined centre- and online-based rehabilitation (COBR) on survivors with initially suboptimal pulmonary functions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Centre-based | Experimental | Centre-based exercise cardiopulmonary rehabilitation program for 6 weeks |
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| Online-based | Experimental | Online-based exercise cardiopulmonary rehabilitation program for 6 weeks |
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| Combined | Experimental | Combined centre- and online-based exercise cardiopulmonary rehabilitation program for 6 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiopulmonary exercise (centre-based) | Other | Depending on the preference of participants, they can either choose to join three 60-minute centre-based sessions plus two sessions of 30-minute home exercise per week, or two 60-minute centre-based sessions plus four sessions of 30-minute home exercise per week. Each session will include warm-up and cool-down exercises, aerobic exercises, and progressive strengthening exercises prescribed based on individual ability (Table 1). Aerobic exercises will be performed at 60-75% (up to 85% for fit individuals) of the predicted maximum heart rate. The respective rate of perceived exertion during exercise will be maintained between 4 and 6 out of 10 on the Borg CR scale [10], indicating moderate to strenuous exercise levels. Additionally, physiotherapists will provide education related to COVID-19, energy conservation, and stress management during the program. |
| Measure | Description | Time Frame |
|---|---|---|
| Fatigue measured by Fatigue Assessment Scale | The Fatigue Assessment Scale is a 10-item scale evaluating symptoms of chronic fatigue.exercise test. | 6 weeks after the start of intervention |
| Fatigue measured by Fatigue Assessment Scale | The Fatigue Assessment Scale is a 10-item scale evaluating symptoms of chronic fatigue.exercise test. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength by 30-second double-leg sit-to-stand test (times) | Muscle strength will be assessed with the 30-second double-leg sit-to-stand test. If the participant can perform the 30-second single leg sit-to-stand test with pain or difficulty, they will be invited to complete 30-second single-leg sit-to-stand test. The number of completed repetitions will be counted. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Siu Ngor Fu, PhD | Contact | 852-27666726 | amy.fu@polyu.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Siu Ngor Fu, PhD | The Hong Kong Polytechnic University | Principal Investigator |
| Loletta Kit-ying So, MD | Pamela Youde Eastern Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pamela Youde Eastern Hospital | Recruiting | Hong Kong | Hong Kong |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Tuen Mun Hospital Hong Kong |
| UNKNOWN |
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| Cardiopulmonary exercise (online-based) | Other | Participants in the OBR group will attend one face-to-face session to learn how to use a mobile application (app) followed by 6 weeks of home exercises. The online treatments will be delivered via the Caspar Health e-system, a German-designed Internet-based system, is available for desktop PCs and as a mobile app for both iOS and Android smartphones. This system will enable patients to follow their therapists' treatment plans in an asynchronous manner. The OBR programme will last for 6 weeks. Participants will be instructed to perform 40 minutes of structured exercises 6 times per week. In the first week, six 40-minute online exercise sessions will be delivered through push notifications on the mobile app. |
|
| Muscle strength by 30-second double-leg sit-to-stand test (times) | Muscle strength will be assessed with the 30-second double-leg sit-to-stand test. If the participant can perform the 30-second single leg sit-to-stand test with pain or difficulty, they will be invited to complete 30-second single-leg sit-to-stand test. The number of completed repetitions will be counted. | 6 weeks after the start of intervention |
| Self-efficacy by 6-Item Chronic Disease Self-Efficacy scale | A six-item digital self-administered self-efficacy questionnaire will be used to evaluate patients' confidence in performing exercise, managing their own symptoms and emotions and completing their daily tasks. | Baseline |
| Self-efficacy by 6-Item Chronic Disease Self-Efficacy scale | A six-item digital self-administered self-efficacy questionnaire will be used to evaluate patients' confidence in performing exercise, managing their own symptoms and emotions and completing their daily tasks. | 6 weeks after the start of intervention |
| Self-perceived quality of life by The St. George's Respiratory Questionnaire-HK version | The St. George's Respiratory Questionnaire-HK version is a self-reported questionnaire. This 50-item disease specific questionnaire assesses 3 domains (symptoms, activity, and impacts). | Baseline |
| Self-perceived quality of life by The St. George's Respiratory Questionnaire-HK version | The St. George's Respiratory Questionnaire-HK version is a self-reported questionnaire. This 50-item disease specific questionnaire assesses 3 domains (symptoms, activity, and impacts). | 6 weeks after the start of intervention |
| Self-perceived quality of life by The Hong Kong Chinese version Short Form-36 | The Hong Kong Chinese version Short Form-36 is a concise 36-item health status questionnaire with good psychometric properties. | Baseline |
| Self-perceived quality of life by The Hong Kong Chinese version Short Form-36 | The Hong Kong Chinese version Short Form-36 is a concise 36-item health status questionnaire with good psychometric properties. | 6 weeks after the start of intervention |
| Cardiac output (L/min) | Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall by a non-invasive measurement of cardiac output using the CardioScreen 1000 System. Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall bilaterally | Baseline |
| Cardiac output (L/min) | Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall by a non-invasive measurement of cardiac output using the CardioScreen 1000 System. Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall bilaterally | 6 weeks after the start of intervention |
| Cardiac stroke volume (ml/m2) | Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall by a non-invasive measurement of cardiac output using the CardioScreen 1000 System. Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall bilaterally | Baseline |
| Cardiac stroke volume (ml/m2) | Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall by a non-invasive measurement of cardiac output using the CardioScreen 1000 System. Non-invasive electrodes will be placed on the clavicle and lateral side of chest wall bilaterally | 6 weeks after the start of intervention |
| Forced expiratory volume in one second (l) | FEV1 is the volume of air that can forcibly be blown out in first 1 second, after full inspiration | Baseline |
| Forced expiratory volume in one second (l) | FEV1 is the volume of air that can forcibly be blown out in first 1 second, after full inspiration | 6 weeks after the start of intervention |
| Forced vital capacity (l) | Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration | Baseline |
| Forced vital capacity (l) | Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration | 6 weeks after the start of intervention |
| FEV1/FVC | Ratio of forced expiratory volume in one second and forced vital capacity | Baseline |
| FEV1/FVC | Ratio of forced expiratory volume in one second and forced vital capacity | 6 weeks after the start of intervention |
| Peak expiratory flow rate (l/s) | Peak expiratory flow (PEF) is the maximal flow (or speed) achieved during the maximally forced expiration initiated at full inspiration | Baseline |
| Peak expiratory flow rate (l/s) | Peak expiratory flow (PEF) is the maximal flow (or speed) achieved during the maximally forced expiration initiated at full inspiration | 6 weeks after the start of intervention |
| Exercise capacity (m) | Exercise capacity will be assessed by the 6-minute walk test (6MWT), a submaximal exercise test. | Baseline |
| Exercise capacity (m) | Exercise capacity will be assessed by the 6-minute walk test (6MWT), a submaximal exercise test. | 6 weeks after the start of intervention |
| Princess Margaret Hospital | Recruiting | Hong Kong | Hong Kong |
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| Queen Elizabeth Hospital | Recruiting | Hong Kong | Hong Kong |
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| Tuen Mun Hospital | Recruiting | Hong Kong | Hong Kong |
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| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |