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Recruitment difficulties and insufficient funding.
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To follow up the cardiopulmonary function after coronavirus disease 2019 (CoVID-19) infection and compare the effect of a 12-week home-based cardiopulmonary with or without add-on remote rehabilitation on the cardiopulmonary function, emotion and quality of outcome.
The investigators will recruit the patients post-CoVID infection for a cardiopulmonary function evaluation and a home-based rehabilitation program. The investigators hypothesize that an add-on remote rehabilitation on a home-based rehabilitation has a better effect than a home-based rehabilitation alone on the compliance rate for the exercise, and also a better outcome in terms of cardiopulmonary function testing, 6-minute walking test, physical activities and quality of life, as well as less dyspnea, depression and anxiety.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Add-on telerehabilitation combined with usual home-based rehabilitation | Experimental | Add-on telerehabilitation combined with usual home-based rehabilitation |
|
| Stand-alone usual home-based rehabilitation | Experimental | Stand-alone usual home-based rehabilitation |
|
| Usual care | No Intervention | Usual care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Add-on telerehabilitation and home-based rehabilitation | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of 6-minute walking test (6MWT) and exercise capacity | The distance of a 6-minute walking test and peak oxygen uptake according to cardiopulmonary exercise test will be assessed before intervention (12-week rehabilitation course), 12 weeks, 6 months and 12 months after intervention. | The change in 6MWT and peak oxygen uptake will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| Measure | Description | Time Frame |
|---|---|---|
| Dyspnea scale | The investigators will assess the change in the Modified Medical Research Council (mMRC) scale. The mMRC scale ranges from 0 to 4. Higher scores indicate worsen symptoms. | The change in mMRC will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| Fatigue |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hung-Jui Chuang, MD | Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Taipei | 100 | Taiwan |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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|
| Home-based rehabilitation alone | Behavioral | 12wk home-based rehabilitation including individualized exercise training and inspiratory muscle training with symptoms monitoring. Participants will be provided with a manual and routine telephone follow-up by a case manager. |
|
The investigators will assess the change in the Brief Fatigue Inventory (BFI). The total score of BFI ranges from 0 to 10. Higher scores indicate greater level of fatigue. |
| The change in BFI will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| Depression and anxiety | The investigators will assess the change in Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder scale (GAD-7). The PHQ-9 score ranges from 0-27 and the GAD-7 score ranges 0-21. Higher scores indicate worsen symptoms. | The change in PHQ-9 and GAD-7 will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| Cognitive evaluation | The investigators will assess the change in Montreal Cognitive Assessment (MoCA). The total score of MoCA ranges from 0 to 30. Higher scores indicate better cognitive function. | The change in MoCA will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| Quality of life evaluation | The investigators will assess the change in EuroQol-5D. | The change in EQ-5D will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| Grip strength | The investigators will assess the grip strength using a grip goniometer with the participants seated and the elbow flexed at 90 degree. | The change in grip strength will be measured at baseline, 12 weeks, 6 and 12 months after intervention. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |