Neuropsychological Indicators of SCD Progression

In Individuals With Subjective Cognitive Decline, Age, Memory and Action Speed Scores at Baseline Predict Progression to Cognitive Impairment

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable.

The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.

Inclusion Criteria:

• patients who had been referred to the memory center at Amiens University Medical Center (Amiens, France).
• patients who had undergone three neuropsychological assessments at least 6 months apart, from 2005
• patients who met the criteria for SCD.

Exclusion Criteria:

• patients who didn't meet the criteria for SCD