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| Name | Class |
|---|---|
| Nanjing Brain Hospital | UNKNOWN |
| The Third People's Hospital of Yunnan Province | OTHER_GOV |
| Central South University | OTHER |
| Beijing academy of science and technology |
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This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.
Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Control group, without specific treatments | |
| Cognitive training | Experimental | This group receives treatments to improve cognitive function. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| multi-modal targeted intervention (e.g., cognitive training, exercise, games) | Combination Product | The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Cognitive function (SCD-9) | The SCD-9 questionnaire is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. |
| Change in Cognitive function (MoCA) | The Montreal Cognitive Assessment test is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. |
| Change in Cognitive function (AD8) | The AD8 test is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. |
| Change in Cognitive function (CDR) | The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants. | Change from Baseline Cognitive test results at 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Physical capacity (TUG) | The timed up and go (TUG) test is used to evaluate physical capacity of participants. | Change from Baseline physical capacity test results at 3 months. |
| Change in Physical capacity (chair standing) |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] | Number of participants with treatment-related adverse events as assessed by CTCAE v5.0. | Up to 24 months. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ying Wang | Contact | 1058122921 | CARM_AD@aliyun.com |
| Name | Affiliation | Role |
|---|---|---|
| Pengxu Wei | National Research Center for Rehabilitation Technical Aids | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Research Center for Rehabilitation Technical Aids | Recruiting | Beijing | Beijing Municipality | 100176 | China |
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| UNKNOWN |
| Beijing University of Chinese Medicine | OTHER |
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The 30-second chair standing test is used to evaluate physical capacity of participants.
| Change from Baseline physical capacity test results at 3 months. |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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