Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma

A Retrospective Study

detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.

renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.

Inclusion Criteria:

• patients suffer from renal cell carcinomas

Exclusion Criteria:

• patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.