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It is well established that a bout of 50 min of continuous moderate intensity exercise, improves insulin sensitivity up to 48 hours after the bout. However, it is less well known, what is the exercise type more efficient to buffer the elevations in blood glucose elicited by carbohydrate ingestion. The purpose of this study is to elucidate if intervalic exercise is superior to continous on improving postprandial glycemic control.
Carbohydrate oxidation, glucose and insulin blood concentrations, isotopically measured rate of appearance of endogenous and exogenous glucose will be measured in 4 ocassions.
Participants will undergo in a cross-over randomized fashion the following trials:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AEROBIC EXERCISE | Active Comparator | 50 min of aerobic exercise by pedaling a cycleergometer at 60% of VO2max |
|
| PLACEBO REST | Placebo Comparator | No exercise, resting during 50 min. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TYPE OF EXERCISE (OR REST) | Behavioral | continous exercise in normal temperature, continous exercise in hot environment, intervallic exercise in normal temperature. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose concentration | Incremental area under the curve during the 120 min of the oral glucose tolerance test | 16 weeks |
| Blood insulin concentration | Incremental area under the curve during the 120 min of the oral glucose tolerance test | 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Carbohydrate oxidation | Measured using indirect calorimetry | 16 weeks |
| Turnover rate of endogenous and exogenous glucose | Measured using isotopic tracers. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo Mora-Rodriguez, PhD | University of Castilla-La Mancha | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Castilla-La Mancha (Exercise Physiology Lab) | Toledo | 45071 | Spain |
Data will be shared upon reasonable request.
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| ID | Term |
|---|---|
| C538376 | Hyperinsulinemic hypoglycemia, familial, 7 |
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Study composed of 4 trials, full-crossover, administered in a randomized order with the inclusion of a control trial.
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| 16 weeks |