TRanscriptomic Analysis of Circulating Endothelial Cells During Sepsis - TRACES Study

Dysfunction and Endothelial Repair in Sepsis Shock : RNAseq Transcriptomic Analysis of Circulating Endothelial Cells

Vascular dysfunction is an important mechanism involved in organ failure, in the setting of sepsis condition, with different types of circulating endothelial cells.Transcriptom analysis via RNAseq in different types of circulating endothelial cells, comapring critically ill patients with or without sepsis will allow determining differential gene expression for signal pathways in endothelial alteration and restoration associated with sepsis.

Inclusion Criteria:

• Age between 18 and 85 years
• Admission in intensive care with or without sepsis
• Health insurance as per the national insurance system
• Informed and unopposed patient for participation (or referend closed one)

Exclusion Criteria:

• Patient under legal protection
• Patient under national medical help system
• Pregnancy