Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States
Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States
Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients. Regrettably, these survivors are at increased risk of new infections but also of cardiovascular disease.
The investigators hypothesize that CS with multi-organ dysfunction is associated with premature senescence of endothelial cells and immune cells and promotes endothelial thrombogenicity and immunosenescence leading to cardiovascular disease and secondary infections.
The aim of this work is therefore to evaluate the contribution of endothelial and leucocytes senescence to the occurrence of secondary events (infectious and cardiovascular) in patients with a CS. It will provide a better understanding of the pathogenesis of cardiovascular and immune diseases following a CS, likely to guide new management strategies to prevent their occurrence.
Inclusion criteria:
Exclusion criteria:
morgane.clerc@chru-strasbourg.fr03 88 11 68 55 ext. +33
madoe.julians@chru-strasbourg.fr03 88 11 61 86 ext. +33
Strasbourg, 67091, France
ferhat.meziani@chru-strasbourg.fr03 69 55 10 24 ext. +33
hamid.merdji@chru-strasbourg.fr03 69 55 11 23 ext. +33