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Optical diagnosis of colorectal polyps is a promising tool to avoid risks of unnecessary polypectomies and to save costs of tissue pathology. NICE (NBI International Colorectal Endoscopic) and WASP (Workgroup on Serrated Polyps and Polyposis) classification were developed for diagnosis of adenomatous and sessile serrated polyps, respectively.
Near-focus (NF) narrow-band imaging (NBI) is an image-magnifying technology which enables optical magnification of up to 65x in near focus (NF) compared with 52x in normal standard focus (SF) with the simple push of a button of the endoscope to be interchangeable between NF and SF. There were few studies comparing diagnostic accuracy between NF and SF in the diagnosis of colorectal polyps. So, our aim of the current study is to compare accuracy of NF NBI compared with SF NBI in the optical diagnosis of neoplastic and non-neoplastic polyp and the accuracy of NF NBI versus SF NBI in distinguishing serrated adenoma from hyperplastic polyp in sessile lesions using histologic evaluation as the gold standard.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Near Focus NBI | Experimental | Use of the Near Focus NBI to make optical diagnosis |
|
| Standard Focus NBI | Active Comparator | Use of the Standard Focus NBI to make optical diagnosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Near Focus NBI | Diagnostic Test | Colonoscopy with near focus narrowing band imaging technology . Optical specifications include a 2 mm near field focal depth. Optical diagnosis of polyps were according to NICE and WASP, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of accurate polyp histology predictions by the Endoscopists in the two groups. | Measure of the percentage of accurate predictions by the endoscopists in the differentiation of neoplastic from non neoplastic colorectal lesions, using the high definition NBI colonoscopy with and without near focus features | At the time of procedure |
| Rate of accurate diagnosis of sessile serrated polyps/adenoma by the Endoscopists in the two groups. | Measure of the percentage od accurate predictions by the endoscopists in the differentiation of sessile serrated polyps/adenoma from hyperplastic polyps, using the high definition NBI colonoscopy with and without near focus features. | At the time of procedure |
| Measure | Description | Time Frame |
|---|---|---|
| The polyp detection rate | The prevalence of patients with at least one polyp was detected | At the time of procedure |
| The adenoma detection rate | The prevalence of patients with at least one adenoma was detected |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| NISA NETINATSUNTON, MD. | NKC Institute of Gastroenterology and Hepatology, Prince of Songkla University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prince Songkla University | Hat Yai | Changwat Songkhla | 90110 | Thailand |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| Standard Focus NBI | Diagnostic Test | Colonoscopy with narrow band imaging technology.Optical diagnosis of polyps were according to NICE and WASP, respectively. |
|
| At the time of procedure |
| Diagnostic Characteristics | Compare the diagnostic characteristic (sensitivity, specificity, positive predictive value and negative predictive value) using the high definition narrow band imaging colonoscopy with and without near focus features. | At the time of procedure |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |