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To assess the benefits and drawbacks of high versus low oxygen therapy on mortality and myocardial function in mechanically ventilated patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conservative oxygen therapy | Active Comparator |
|
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| Liberal oxygen therapy | Placebo Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxygen | Drug |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Stroke volume in milliliters | Volume of blood in milliliters that is ejected from heart each second and measured By Echocardiography | Change from Baseline stroke volume At ICU admission and through study completion An average 6 months |
| Change in ejection fraction of heart in percentage | percentage of blood that's pumped out of a filled ventricle with each heartbeat And measured by echocardiography | Change from baseline ejection fraction at icu admission and through study completion An Average 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Acute respiratory distress syndrome | Acute persistent hypoxia with bilateral lung infiltrate due to non cardiac cause | From icu admission date to icu discharge date an average of 2 weeks |
| Sepsis |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aswan university hospital | Aswān | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39707209 | Derived | Ghazaly HF, Aly AAA, Tammam AS, Hassan MM, Hammad SS, Mahmoud NM, Hemaida TS. Influence of liberal versus conservative oxygen therapies on the hemodynamic parameters of mechanically ventilated patients with sepsis: a randomized clinical trial. BMC Anesthesiol. 2024 Dec 20;24(1):469. doi: 10.1186/s12871-024-02838-6. |
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| ID | Term |
|---|---|
| D010100 | Oxygen |
| ID | Term |
|---|---|
| D018011 | Chalcogens |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |
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Systolic blood pressure < 90 Respiratory rate > 22 Heart rate > 100
| From icu admission date to icu discharge date an average of 2 weeks |
| Stroke | Cerebrovascular accidents | From icu admission date to icu discharge date an average of 2 weeks |
| Mechanical Ventilator free days | Days without mechanical ventilation | From icu admission date to icu discharge date an average of 2 weeks |
| Shock | Systolic blood pressure < 90 mmHg | From icu admission date to icu discharge date an average of 2 weeks |
| Surgery revision | Surgical re exploration | From icu admission date to icu discharge date an average of 2 weeks |
| Vasopressor | Use of vasopressors as norepinephrine and epinephrine | From icu admission date to icu discharge date an average of 2 weeks |
| ICU stay | Duration of intensive care stay | From icu admission date to icu discharge date an average of 2 weeks |
| Hospital stay | Duration of hospital stay | From icu admission date to icu discharge date an average of 2 weeks |
| Mortality | Death of patient | From icu admission date to icu discharge date an average of 2 weeks |