The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) toped flap debridement (OFD) in periodontitis patients.

Thirty (30) intrabony defects are randomly divided in two treatment groups: test (n = 15) and control (n = 15). The intrabony defects are filled with A-PRF+ (n=15) in the test group, respectively treated with open flap debridement in the control group, and fixed with sutures to ensure wound closure and stability.

Inclusion Criteria:

• no systemic diseases
• a good level of oral hygiene
• presence of a 2-, 3-, or combined 2-3-wall intrabony defect with a defect angle of 20-40 (+/- 5) degrees
• with a minimum PPD of 6 mm and intrabony component of a minimum 4 mm as detected on radiographs
• no smoking

Exclusion Criteria:

• systemic diseases that could influence the outcome of the therapy
• poor oral hygiene
• smoking
• horizontal bone loss