Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin

Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin and Titanium Platelet Rich Fibrin: A Randomized Clinical Comparative Study

Background: To compare the effectiveness of open flap debridement (OFD) alone and OFD along with either Autologous Platelet Rich Fibrin (PRF) or Titanium Platelet Rich Fibrin (TPRF) in the treatment of intrabony defects (IBDs).

Materials and methods: Study was conducted on subjects reporting to the Department of Periodontics, The Oxford Dental College and Hospital, Bangalore. 38 subjects with 90 periodontal IBDs of moderate to severe periodontitis were selected and assigned to OFD alone (group I) or OFD with Autologous PRF (group II) or OFD with TPRF (group III). In each subject, a minimum number of two sextants were present with probing pocket depths (PPD) ≥5mm in at least three teeth.

Inclusion Criteria:

• presence of minimum 20 permanent teeth
• age group 20-55 years
• radiographic evidence of periodontal IBDs
• probing pocket depth (PPD) >5mm in minimum two sextants in at least three teeth
• clinical attachment (CA) loss of ≥ 3mm.

Exclusion Criteria:

• Systemically compromised subjects
• those on medications (corticosteroids/ bisphosphonate therapy) that may interfere with wound healing
• grade III tooth mobility
• smokers and alcoholic subjects
• pregnant and lactating mothers
• subjects who underwent periodontal treatment within a period of 1 year.