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| ID | Type | Description | Link |
|---|---|---|---|
| RFA-IMPACT-20-P02A | Other Grant/Funding Number | NIA | |
| U54AG063546 | U.S. NIH Grant/Contract | View source |
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Principal Investigator is taking a leave of absence. Study terminated.
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| Name | Class |
|---|---|
| Advarra | INDUSTRY |
| National Institute on Aging (NIA) | NIH |
| Brown University | OTHER |
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Pilot study to evaluate the feasibility of a pilot embedded pragmatic cluster randomized controlled trial to reduce the duration of antibiotic therapy and number of antibiotic prescriptions in nursing home residents with AD/ADRD.
The overall objective of the proposed investigation is to assess the feasibility of a pilot embedded pragmatic cluster randomized controlled trial (ePCT) to reduce the duration of antibiotic therapy and number of antibiotic prescriptions among nursing home residents with AD/ADRD. With the support of three independently owned and operated nursing homes that are unaffiliated with an academic medical center, we have developed the multicomponent intervention, eCARE-ID (Electronic Consultation for AD/ADRD Residents Experiencing Infectious Diseases). eCARE-ID consists of three components: 1) Tele-ID video clinical consultation services for nursing home residents; 2) electronic consultation (e-consultation) services for healthcare personnel at participating nursing homes; and 3) Tele-ID video antibiotic stewardship services for healthcare personnel including pharmacists at participating nursing homes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Two nursing homes will receive the eCARE-ID intervention |
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| Control | Placebo Comparator | One control nursing home will receive infectious disease consultations and antibiotic stewardship services per routine practice. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| eCARE-ID | Device | The intervention, eCARE-ID, consists of: 1) telehealth video clinical consultation services for nursing homes residents; 2) electronic consultation services for healthcare personnel; 3) telehealth video antibiotic stewardship services for healthcare personnel |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of antibiotic therapy in nursing home residents | The primary outcome will be defined as the duration of antibiotic therapy in nursing home residents with AD/ADRD, measured as the total days of antibiotic therapy per 1000 resident-days among residents with ADRD. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of antibiotic prescriptions in nursing home residents | The secondary outcome will be defined as the number of antibiotic prescriptions in nursing home residents with AD/ADRD, defined as the total number of antibiotic prescriptions per 1000 resident-days among residents with AD/ADRD. | 6 months |
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Inclusion criteria - residence in a participating nursing home
Exclusion criteria:
- Not willing to consent to the study
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| Name | Affiliation | Role |
|---|---|---|
| Manisha Juthani-Mehta, M.D. | Yale University | Principal Investigator |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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Two participating nursing homes will be assigned to the intervention. One participating nursing home will serve as a control.
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| Standard of Care | Other | Standard of care will be delivered to the control home. |
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| D019636 |
| Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |