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Retrospective and confounder adjusted comparison of perioperative and longterm outcomes of patients requiring an esophagectomy for esophageal cancer with and without concomitant liver cirrhosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LC (liver cirrhotic patients) | Patients with concomitant liver cirrhosis |
| |
| Non-LC (non liver cirrhotic patients) | Patients without concomitant liver cirrhosis |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| surgery | Procedure | retrospective comparison of esophagectomy for esophageal cancer in patients with or without concomitant liver cirrhosis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Long-term survival | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Major complication | Clavin Dindo ≥ 3 | 90 days postoperatively |
| Anastomotic leakage rate | Rate of endoscopically diagnosed anastomotic leakage |
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Inclusion Criteria:
Exclusion Criteria:
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retrospective analysis of a prospective maintained database of EC patients operated at the institution between 2012 to 2016
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| Name | Affiliation | Role |
|---|---|---|
| Reeh, MD | 1Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hamburg Medical Institutions | Hamburg | Germany |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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| 90 days postoperatively |
| Sepsis rate | Rate of participants with ≥ 2 points in Sepsis-related organ failure (SOFA) score within hospital stay | 90 days postoperatively |
| Renal failure rate | Rate of acute kidney insufficiency (AKI) II-III (AKI Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines) | 90 days postoperatively |
| Hepatic failure rate | Number of participants with clinical diagnosis: coagulopathy, icterus and potentially hepatic encephalopathy | 90 days postoperatively |
| Cardiac complication | cardiac complication requiring pharmacological treatment or intervention and / or ICU surveillance | 90 days postoperatively |
| Chylus fistula rate | Concentration of triglycerides (TG) in drain fluids ≥ 3 times TGs i.s. | 90 days postoperatively |
| Pulmonary complications | Pneumonia requiring antibiotics, ventilatory insufficiency requiring supportive therapy | 90 days postoperatively |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D008107 | Liver Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |