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This study intends to investigate the effects of desflurane on postoperative sleep quality to guide perioperative patient management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Desflurane Inhalation Group | Experimental | Anesthesia maintenance: Desflurane inhalation (MAC 1.0-1.2) Sufentanil 0.3-0.5 μg / (kg·h) Cisatracurium 1-3 μg / (kg·min) |
|
| Propofol Group | Active Comparator | Anesthesia maintenance: Propofol TCI: 3-4ug / ml Sufentanil 0.3-0.5 μg / (kg·h) Cisatracurium 1-3 μg / (kg·min) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Desflurane Inhalation | Drug | Subjects were randomized in a 1:1 ratio to undergo breast surgery under maintenance of anesthesia with the classical intravenous anesthetic drug propofol (reference group) or the inhaled anesthetic drug desflurane (test group). |
| Measure | Description | Time Frame |
|---|---|---|
| Pittsburgh sleep quality index | Postoperative 3rd day |
| Measure | Description | Time Frame |
|---|---|---|
| Pittsburgh sleep quality index | Postoperative 7th, and 30th days | |
| Total sleep time (TST), Rapid eye movement time (REM), Wakefulness after sleep onset (WASO) | Fitbit Charge 2â„¢ objectively measured |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongnan Hospital of Wuhan University | Wuhan | Hubei | 430071 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39038404 | Derived | Wang X, Xiong B, Wu T, Liu X, Li K, Wang S, Deng MG, Peng M. Effect of desflurane maintenance on postoperative sleep quality in patients undergoing elective breast surgery: A non-inferiority randomized controlled trial. Sleep Med. 2024 Sep;121:287-294. doi: 10.1016/j.sleep.2024.07.022. Epub 2024 Jul 17. |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| Postoperative 1st, 2nd, and 3rd days |
| Self-Rating Anxiety Scale Scores | Postoperative 3rd, 7th, and 30th days |
| Self-Rating Depression Scale Scores | Postoperative 3rd, 7th and 30th days |
| Visual analogue scale scores | Postoperative 3rd, 7th and 30th days |
| Flurbiprofen dose | Postoperative 1st, 2nd, and 3rd days |
| Recovery time and quality (steward scores) | Up to 2 hours after operation |
| D017437 |
| Skin and Connective Tissue Diseases |