D-chiro Inositol in Prevention of Gestational Diabetes Mellitus in China

D-chiro Inositol in Prevention of Gestational Diabetes Mellitus in High Risk Pregnant Women in China

Inositol is a type of food additives, which plays an important role in insulin signal pathway and is related to insulin sensitivity. Our randomized, double-centered, placebo-controlled study is planned to recruit 360 pregnant women who is in high risk for gestational diabetes. They will be assumed randomly 1 g of D-chiro inositol per day or placebo from 12-16th gestational weeks until Oral Glucose Tolerance Test (OGTT) at 24-28th gestational weeks. Perinatal outcomes about delivery time, neonatal weight will be registered.

Inclusion Criteria:

• During 12-16 weeks gestation
• Meet any of the following: prepregnancy BMI > 24, family history of diabetes (type 1 or 2), GDM history, history of delivering macrosomia, gestational history of stillbirth;
• Willing to participate

Exclusion Criteria:

• Type 1 or type 2 diabetes mellitus diagnosed before pregnancy
• Multiple gestation
• Mental or cognitive impairment cannot complete the study