Effect of Exercise on GDF-15 Levels in Prediabetic Patients

Effect of Exercise on GDF-15 Levels in Prediabetic Patients

The aim of this study is to evaluate whether there is a change in GDF-15 levels in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program with guide-based exercise programs.

GDF-15, which has anorexigenic effects, increases with exercise. In prediabetic patients, GDF-15 is higher than healthy controls. The effect of exercise on GDF-15 levels in prediabetic patients is unknown.

The aim of this study is to evaluate whether there is a change in GDF-15 levels after the application of guideline-based exercise programs in individuals with prediabetes at the 2nd hour after the first exercise and after a 12-week exercise program.

Inclusion Criteria:

• Body mass index 30-34.9 kg / m2
• Sedentary life-style (Physical activity below 300 kcal / day will be assessed by Minnesota Leisure Physical Activity Questionnaire)
• Those who have sufficient motivation to participate in the exercise program (will be evaluated by face-to-face interview by the researchers)
• Having the same weight for 6 months before participating in the study (± 2.5 kg)
• Those diagnosed with prediabetes by oral glucose tolerance test and / or HbA1c measurement will be included.

Exclusion Criteria:

• Serious medical condition (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.)
• Having cardiovascular disease
• Having diabetes
• Using metformin
• Taking hormone replacement therapy
• less than 1 year life expectancy
• HIV positivity
• Substance use
• Functional dependence
• Cognitive weakness
• Those with other diseases that will affect the study result (respiratory diseases, muscle diseases, etc.)
• Those who use drugs or supplements that will affect the results of the study