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| Name | Class |
|---|---|
| Combined Military Hospital Nowshera | OTHER_GOV |
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This study is being done to compare the effect of regular exercise and metformin in people who have prediabetes. It is a community-based, open-label, randomized trial in which eligible participants will be divided into two groups. One group will do moderate physical exercise, and the other group will take metformin for 12 weeks. We will check their fasting blood sugar and HbA1c before and after the treatment to see which method works better for controlling sugar levels. The study is being done in a low-resource community setup to see which option is more practical and effective in real-life Pakistani settings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Group | Experimental | Moderate aerobic activity (e.g., brisk walking) for 30-45 minutes/day, 5 days/week, for 12 weeks. |
|
| Metformin Group | Active Comparator | Participants will receive oral metformin 500 mg twice daily for 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderately intense exercise | Behavioral | Structured moderate-intensity aerobic activity (e.g., brisk walking) for 30-45 minutes/day, 5 days/week, for 12 weeks. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Glycated Hemoglobin (HbA1c) from Baseline to 12 Weeks | HbA1c (%) will be measured to assess glycemic improvement following 12 weeks of intervention. | Baseline and 12 week |
| Measure | Description | Time Frame |
|---|---|---|
| Weight change | Change in weight in kilograms from baseline to 12 weeks following the two interventions | Baseline to 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Umair Ali | CMH Nowshera | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Preventive Medicine, Combined Military Hospital Nowshera | Nowshera | 25770 | Pakistan |
To maintain patients confidentiality
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| ID | Term |
|---|---|
| D018149 | Glucose Intolerance |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008687 | Metformin |
| D013607 | Tablets |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D004304 |
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| MetFORMIN 500 Mg Oral Tablet | Drug | Participants will receive oral metformin 500 mg twice daily for 12 weeks. |
|
|
| D001519 | Behavior |
| Dosage Forms |
| D004364 | Pharmaceutical Preparations |