The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.

Early intervention of CBP can remove inflammatory factors in patients with sepsis and reduce the damage of inflammatory factors to organs; at the same time, it can also promote the body's immune response, significantly improve immune dysfunction, and restore the body's immune balance. However, the timing of early application of CBP in childhood sepsis is still unclear. Therefore, it is necessary to further explore the treatment and prognosis of this technology in the early treatment of sepsis.

Inclusion Criteria:

• Age of 29d to 18 years old;
• Children diagnosed with sepsis requiring blood purification.

Exclusion Criteria:

• with a history of a duration of PICU stay <24 h
• active bleeding, including cerebral hemorrhage

children with sepsis requiring blood purification to prevent or treat fluid overload or to clear cytokines