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The immunomodulatory effects of vitamin D are known to be beneficial in viral infections, it is also known that its deficiency is associated with a worse prognosis of COVID-19. This study aimed to determine the baseline vitamin D serum concentrations in asymptomatic or mildly symptomatic COVID-19 outpatients, as well as to evaluate the effects of supplementation with 10,00 IU/daily of vitamin D3 and its relationship with biochemical parameters and clinical features.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | Formed by 22 patients that received oral supplementation of 10,000 IU daily for fourteen days of vitamin D3 |
|
| Control group | No Intervention | Formed by 20 patients that did not receive supplementation |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin D3 | Dietary Supplement | Patients received oral supplementation of 10,000 IU daily for fourteen days of vitamin D3 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Baseline levels of serum vitamin D in COVID-19 patients | Evaluate serum levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico | At baseline |
| Correlation between D-dimer and vitamin D serum levels in COVID-19 patients | Serum levels of D-dimer (ng/mL) will be measured at baseline and correlated with levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico | At baseline |
| Correlation between transferrin and vitamin D serum levels in COVID-19 patients | Serum levels of transferrin (mg/dL) will be measured at baseline and correlated with levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico | At baseline |
| Correlation between ferritin and vitamin D serum levels in COVID-19 patients | Serum levels of ferritin (ng/mL) will be measured at baseline and correlated with levels of 25(OH)D (ng/mL) in patients with covid-19 from western Mexico | At baseline |
| Effects of vitamin D3 supplementation on COVID-19 patients | Serum levels of 25(OH)D (ng/mL) will be determined in the intervention group after 14 days of Vitamin D3 supplementation | After 14 days of supplementation |
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Inclusion criteria:
Exclusion criteria:
• Diseases that compromise the absorption of Vitamin D; Crohn's disease, cystic fibrosis, and celiac disease.
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| Name | Affiliation | Role |
|---|---|---|
| José F Muñoz-Valle, Dr. | University of Guadalajara | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad de Guadalajara | Guadalajara | Jalisco | 44340 | Mexico |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |