Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The primary objective of this study is to investigate the effects of strawberries on cognitive responses, motor control function, and vascular and cardiometabolic risk markers in healthy older adults.
To achieve the objectives, 40 healthy men and women ≥65 years of age will consume 26 g of freeze-dried strawberries in the form of a drink-mix daily for 8 wk. Using a randomized crossover study design, the effects will be compared to the effects of 8 wk intake of a placebo drink-mix (with a 4 wk wash-out period between trials). Cognitive function measurements will be performed at baseline and 8 wk. Additionally, at each timepoint, flow-mediated vasodilation and blood pressure will be measured followed by collection of fasting blood samples to assess glucose, insulin, blood lipids (free fatty acids, triacylglycerol, total cholesterol, LDL cholesterol, and HDL cholesterol), inflammatory markers (interleukins 6 and 18), and markers of oxidative stress (oxidized LDL-C and malondialdehyde).
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Strawberry powder | Experimental | Participants consume 1 package of standard strawberry powder (26 g) daily for 8 weeks |
|
| Placebo group | Placebo Comparator | Participants consume 1 package of placebo powder (26 g) daily for 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strawberry | Other | Freeze dried strawberry powder |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in processing speed (cognition) at 8 weeks | using Pattern Comparison Processing Speed Test | At baseline, at 8 weeks |
| Change from baseline in executive function (cognition) at 8 weeks | using Dimensional Change Card Sort Test; Flanker Inhibitory Control and Attention Test | At baseline, at 8 weeks |
| Change from baseline in working memory (cognition) at 8 weeks | using List Sorting Working Memory Test | At baseline, at 8 weeks |
| Change from baseline in episodic memory (cognition) at 8 weeks | using Picture Sequence Memory Test | At baseline, at 8 weeks |
| Change from baseline in working memory (cognition) at 8 weeks | using Picture Vocabulary Test; Oral Reading Recognition Test | At baseline, at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Vascular health at 8 weeks | to better understand how changes in the gut microbiota through fruit consumption are linked to changes in health outcomes, we will assess endothelial function via flow-mediated vasodilation and risk factors for cardiometabolic dysfunction in fasting blood samples collected at baseline and after 8 weeks. | At baseline, at 8 weeks |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shirin Hooshmand | San Diego | California | 92182-7251 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40199714 | Derived | Delaney K, Tsang M, Kern M, Rayo VU, Jason N, Hong MY, Liu C, Hooshmand S. Strawberries modestly improve cognition and cardiovascular health in older adults. Nutr Metab Cardiovasc Dis. 2025 Aug;35(8):104018. doi: 10.1016/j.numecd.2025.104018. Epub 2025 Mar 18. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Using a randomized crossover study design, the effects will be compared to the effects of 8 wk intake of a placebo drink-mix (with a 4 wk wash-out period between trials).
Not provided
Not provided
Not provided
Not provided
| Placebo group |
| Other |
Comparative placebo powder |
|