Study on the Application of Saliva EBV-DNA Detection in EBV Infection Related Diseases

A Prospective Study on the Application of Saliva EBV-DNA Detection in EBV Infection Related Diseases

This study is a single-center, prospective, observational clinical study to evaluate the Application of saliva EBV-DNA Detection in EBV Infection Related Diseases

Inclusion Criteria:

1. According to the HLH-04 diagnostic criteria, it meets the HLH diagnostic criteria. EBV infection occurs in cells with EBV-DNA copy number significantly increased in peripheral blood or tissue, or where EBV coding small RNA(EBER) is detected in tissue or peripheral blood. Or Straus' 1988 diagnostic criteria for CAEBV.
2. Informed consent

Exclusion Criteria:

1. Patients who cannot cooperate with saliva collection
2. Patients who are unwilling to cooperate with the project research according to the project research plan.