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Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells. While the amount of DNA damage that may occur from one scan is not harmful to your overall health, there could be concerning damage in patients who are constantly exposed to this radiation. Currently, there is no way to prevent DNA damage during a medical scan. One potential way to fight the oxidative stress caused by radiation is to take an antioxidant before a scan. The purpose of this study is to see if a combination of antioxidants can protect someone from the damage that radiation causes to the DNA of their white blood cells.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multi-nutrient supplement | Experimental |
| |
| Placebo supplement | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multi-nutrient supplement | Drug | Multi-nutrient supplement containing a combination of vitamins, minerals and antioxidants |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of gamma-H2Ax foci per PBMC nucleus | Number of gamma-H2Ax foci per PBMC nucleus three hours following radiation exposure | Three hours following radiation exposure |
| Measure | Description | Time Frame |
|---|---|---|
| Amount of amplifiable mtDNA in PBMC's | Amount of amplifiable mtDNA in PBMC's three hours following radiation exposure | Three hours following radiation exposure |
| Abundance of mtDNA deletions in PBMC's |
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Inclusion Criteria:
Exclusion Criteria:
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All IPD that underlie results in a publication
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| Placebo | Drug | Placebo |
|
Abundance of mtDNA deletions in PBMC's three hours following radiation exposure
| Three hours following radiation exposure |
| Abundance of phosphorus-ATM in PBMC's | Abundance of phosphorus-ATM in PMBC's three hours following radiation exposure | Three hours following radiation exposure |