Study of Antioxidants on MRI Detectable Early Stage Prostate Cancer Among Men on Active Surveillance

The Impact of Antioxidants on MRI Markers of Cell Proliferation and Hypoxia Among Men on Active Surveillance With Early Stage Prostate Cancer

The purpose of this study is to determine whether antioxidants (vitamin E, selenium and lycopene)can change(reduce)prostate tumor size or blood flow to the prostate as determined by MRI imaging among men on Active Surveillance.

Inclusion Criteria:

• MRI detectable prostate cancer
• PSA less than 15 ng/ml
• Gleason score <= 7
• Prostate cancer staging T1c or T2a

Exclusion Criteria:

• Concurrent use of high-dose vitamins which include selenium, lycopene, vitamin D or vitamin E
• Other malignancies diagnosed or requiring treatment within the past 5 years (except superficial bladder cancer or basal cell carcinoma)
• Current use of Proscar or Avodart