An Exploratory PET-study of Deposition, Disposition and Brain Uptake of [11C]Nicotine After Inhalation of 2 Nicotine Formulations Via the myBluTM E-cigarette in Smokers

An Exploratory PET-study of Deposition, Disposition and Brain Uptake of [11C]Nicotine After Inhalation of 2 Nicotine Formulations Via the myBluTM E-cigarette in Smokers

This is a single-center, exploratory positron emission tomography (PET) study of deposition, disposition and brain uptake [11C]nicotine when given to smokers as two different formulations via mybluTM e-cigarette system.

Inclusion Criteria:

• Body mass index ≥18.0 and ≤ 30.0 kg/m2
• Habitual daily cigarette smoker
• Women have to be of non-child bearing potential

Exclusion Criteria:

• History of any clinically significant disease
• Relevant concomitant medication
• Any clinically significant condition
• Malignancy within the past 5 years
• Positif for HIV, hepatitis B or C
• Untreated hypertension
• Previous participation to a PET-study or other nuclide medical study
• Previous exposure to significant radiation
• Negative results of the modified Allen test on both arms at screening
• Alcohol or drug abuse