Nicotine Uptake and Abuse Liability Assessments of Blu Disposable Electronic Cigarettes

Nicotine Uptake and Abuse Liability Assessments of 5 Blu Disposable Electronic Cigarettes in Comparison to a Combustible Cigarette

This study assesses the nicotine uptake, abuse liability and puffing topography of blu disposable e-cigarettes in adult combustible cigarette smokers. Nicotine uptake, subjective effects, and puff topography are evaluated and compared with subjects' usual brand combustible cigarette.

Inclusion Criteria:

• Subjects must be current smokers (≥10 per day) of combustible cigarettes for at least 6 continuous months before Visit 1 and may be occasional users of e-cigarettes

• Subjects have urine cotinine >200 ng/mL and exhaled carbon monoxide > 10 ppm at Screening

• Subject has a seated systolic blood pressure ≤160 mmHg, diastolic blood pressure

  ≤95 mmHg, and heart rate ≤100 bpm

• Females of childbearing potential who are practicing a reliable method of contraception

Exclusion Criteria:

• Subjects who have used any nicotine or tobacco product other than e-cigarettes or combustible cigarettes in the 14 days prior to Visit 1
• Subjects who have an acute illness requiring treatment in the 4 weeks prior to Visit 1
• Subjects with clinically significant and relevant abnormalities of medical history.
• Subjects who have used any prescription or over-the-counter smoking cessation treatments within 30 days prior to Visit 1
• Pregnant or breastfeeding female subjects