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| Name | Class |
|---|---|
| The University of Hong Kong | OTHER |
| Tuen Mun Hospital | OTHER_GOV |
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The proposed study aims to determine if transcranial direct current stimulation can enhance the effect of speech therapy in post-stroke patients with dysarthria.
A total of 60 Cantonese-speaking post-stroke patients who are suffering from dysarthria will be recruited and randomly divided into real tDCS and sham groups. All the participants will receive individualized speech therapy based on the results of their speech assessment.
For the real tDCS group, an anodal high-definition tDCS of 2 milliamperes (mA) lasting for 20 minutes will be delivered to the orofacial area of the primary motor cortex (SM1) during speech therapy. For the sham tDCS group, stimulation given during speech therapy will only last for 30 seconds in order to cause a similar sensation on the scalp as the real stimulation group. There will be a total of 10 daily sessions during a 2-week period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| real tDCS | Experimental | A total of 60 Cantonese-speaking post-stroke patients who are suffering from dysarthria will be recruited and randomly divided into real tDCS and sham groups. |
|
| sham tDCS | Sham Comparator | A total of 60 Cantonese-speaking post-stroke patients who are suffering from dysarthria will be recruited and randomly divided into real tDCS and sham groups. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS active | Device | An anodal high-definition tDCS of 2 mA lasting for 20 minutes will be delivered to the orofacial area of the primary motor cortex (SM1) during speech therapy. |
| Measure | Description | Time Frame |
|---|---|---|
| Perceptual speech assessments | All participants will be required to produce a sustained vowel /a/, repeat some syllables (i.e., /pa/, /ta/, /ka/ and /pataka/), read a standard Chinese paragraph and have a 1-2 mins conversation with the researcher. | Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment |
| Communication effectiveness measures | The Modified Communication Effectiveness Index (CETI-M) is a 10-item patient-reported measure of change in functional communication ability. | Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Kinematic Measurements | The lip and tongue function during speech production will be traced real time and objectively using the 3D-Electromagnetic Articulography (EMA, AG501-system). | Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment |
| Acoustic measurements |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Min Ney Wong, PhD | The Hong Kong Polytechnic University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hong Kong Polytechnic University | Hong Kong | Hong Kong |
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| ID | Term |
|---|---|
| D004401 | Dysarthria |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D001184 | Articulation Disorders |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
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| tDCS sham | Device | An anodal high-definition tDCS of 2 mA lasting for 30 seconds will be delivered to the orofacial area of the primary motor cortex (SM1) during speech therapy. |
|
Acoustic measurements will be obtained from both sustained vowel phonation and connected speech. |
| Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment |
| Quality of Life measurement | The Chinese version of The Quality of Life of the Dysarthric Speaker (QOL-DyS) questionnaire will be used to assess participants' subjective speech related quality of life. | Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment |
| D019954 |
| Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |