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The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.
The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.
This randomized, placebo-controlled, double-blinded pilot study will recruit ten chronic stroke patients with Broca's Aphasia randomly assigned either to sham or an anodal tDCS groups. Following speech and language assessment, all the participants will receive 20 minutes of individualized language therapy daily for ten days in two consecutive weeks. Simultaneously, the treatment group will receive 20 minutes of 2mA anodal HD-tDCS over the left IFG, while the sham group will receive the 30s of 2mA anodal HD-tDCS. Structural, resting state and task activated functional MRI will be performed. Data acquisition will be performed before, immediately after and two months after the treatment.
Repeated measure ANOVA for changes in picture-naming accuracy and response time will be performed as a within-subject factor between sham and anodal tDCS. Pearson's correlation coefficient of left IFG and its homolog in the right hemisphere through Independent component analysis (ICA) of low-frequency fluctuations in resting-state and task activated state will be compared for functional connectivity analysis for IFG and other major languages hubs for oral language production between groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real tDCS | Experimental | Five post-stroke patients will be allocated by the flip the coin method to the experimental group. Participants will receive anodal tDCS stimulation for 20 minutes |
|
| Sham tDCS | Sham Comparator | Five participants will be allocated by the flip coin method to the sham comparator group. Participants will receive the tDCS stimulation for the 30s |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Real tDCS | Device | An anodal high-definition tDCS of 2 mA lasting for 20 minutes will be delivered to the left inferior frontal gyrus during speech therapy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Picture naming | Picture-naming accuracy and response time for each stimuli will be determined perceptual and calculated using praat software | Change before, immediately after and two months after the treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Imaging analysis | Mapping changes in functional connections of language networks, inter-hemispheric and intra-hemispheric regions of the brain. | Change before, immediately after and two months after the treatment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Min Ney WONG, PhD | Contact | (852) 27667268 | min.wong@polyu.edu.hk | |
| Faisal N Baig, PhD | Contact | (852) 27666561 | faisal.n.baig@polyu.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Min Ney Wong, PhD | The Hong Kong Polytechnic University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hong Kong Polytechnic University | Recruiting | Kowloon | Hong Kong |
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| ID | Term |
|---|---|
| D001037 | Aphasia |
| D020521 | Stroke |
| D003147 | Communication Disorders |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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Double (participant, outcome accessor)
| Sham tDCS | Device | An anodal high-definition tDCS of 2 mA lasting for 30 seconds will be delivered to the left inferior frontal gyrus during speech therapy. |
|
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |