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| Name | Class |
|---|---|
| University Medical Center Rostock | OTHER |
| Medical Department II, Division of Gastroenterology, University Hospital of Leipzig | UNKNOWN |
| Ludwig-Maximilians - University of Munich | OTHER |
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This study is a multicentric prospective study initiated and coordinated from the University Medical Centre Goettingen. The study aims to evaluate the orointestinal microbiome as a potential biomarker for the course, severity and outcome of patients with acute pancreatitis.
This prospective translational study aims to evaluate the orointestinal microbiome as a potential biomarker for the course, severity and outcome of patients with acute pancreatitis. From each patient one buccal and rectal swab is collected within 72 h after hospital admission. Microbial composition will be determined by 16S and metagenomics Oxford Nanopore Sequencing (ONT) and correlated with the revised Atlanta classification as the primary endpoint. Secondary endpoints are the correlation of microbiome signatures with the length of hospital stay, numbers of interventions and mortality. To this end, alpha and beta diversity of microbiota are determined and compared between mild, moderately severe and severe acute pancreatitis.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rectal and buccal swabs | Diagnostic Test | The oral and intestinal flora is collected from buccal and rectal swabs. |
| Measure | Description | Time Frame |
|---|---|---|
| Revised Atlanta classification I-III | Microbial composition (alpha and beta-diversity) will be correlated with the revised Atlanta classification. | up to 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | days in hospital during initial admission | up to 12 months |
| Numbers of interventions (surgical and endoscopical) | number of percutaneous drainages, number of EUS-guided interventions of infected necrotic or acute collections, type of drainages (plastic versus lumen apposing metal stents), number of open surgical interventions |
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Inclusion Criteria:
Patients with acute pancreatitis (2 out of 3 following diagnostic criteria: lipase >3x of upper limit, abdominal pain, and imaging modalities (computed tomography, magnetic resonance imaging or ultrasound).
< 72 hours after hospital admission.
Exclusion Criteria:
Pregnant women Patients < 18 years; Patients who are incapable of giving consent
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Centre Göttingen | Göttingen | 37075 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32703080 | Background | Ammer-Herrmenau C, Pfisterer N, Weingarten MF, Neesse A. The microbiome in pancreatic diseases: Recent advances and future perspectives. United European Gastroenterol J. 2020 Oct;8(8):878-885. doi: 10.1177/2050640620944720. Epub 2020 Jul 23. | |
| 38129103 | Background | Ammer-Herrmenau C, Antweiler KL, Asendorf T, Beyer G, Buchholz SM, Cameron S, Capurso G, Damm M, Dang L, Frost F, Gomes A, Hamm J, Henker R, Hoffmeister A, Meinhardt C, Nawacki L, Nunes V, Panyko A, Pardo C, Phillip V, Pukitis A, Rasch S, Riekstina D, Rinja E, Ruiz-Rebollo ML, Sirtl S, Weingarten M, Sandru V, Woitalla J, Ellenrieder V, Neesse A. Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis. Gut. 2024 Feb 23;73(3):485-495. doi: 10.1136/gutjnl-2023-330987. |
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| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
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| Department of Medicine I, University Hospital of Halle | UNKNOWN |
| Department of Medicine A, University Medicine Greifswald | UNKNOWN |
| Technical University of Munich | OTHER |
| Department of Medical Bioinformatics, University Medical Center Göttingen | UNKNOWN |
| Department if Medical Statistics, University Medical Center Göttingen | UNKNOWN |
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| up to 12 months |
| Mortality | in hospital mortality during initial admission (%) | up to 12 months |
| 41298102 | Derived | Ammer-Herrmenau C, Meier R, Antweiler KL, Asendorf T, Cameron S, Capurso G, Damm M, Dang L, Frost F, Hamm J, Hoffmeister A, Kocheva Y, Meinhardt C, Nawacki L, Nunes V, Panyko A, Ruiz-Rebollo ML, Florez-Pardo C, Phillip V, Pukitis A, Vaselane D, Rinja E, Sandru V, Schaefer A, Scholz R, Seelig J, Sirtl S, Ellenrieder V, Neesse A. Gut microbiota predict development of postdischarge diabetes mellitus in acute pancreatitis. Gut. 2026 Jan 8;75(2):316-325. doi: 10.1136/gutjnl-2025-336715. |
| 34332533 | Derived | Ammer-Herrmenau C, Asendorf T, Beyer G, Buchholz SM, Cameron S, Damm M, Frost F, Henker R, Jaster R, Phillip V, Placzek M, Ratei C, Sirtl S, van den Berg T, Weingarten MJ, Woitalla J, Mayerle J, Ellenrieder V, Neesse A. Study protocol P-MAPS: microbiome as predictor of severity in acute pancreatitis-a prospective multicentre translational study. BMC Gastroenterol. 2021 Jul 31;21(1):304. doi: 10.1186/s12876-021-01885-4. |