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Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery.Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling. The clot formed in chronic thromboembolic pulmonary hypertension does not melt and turns into a fibrous state, it occludes the pulmonary artery.In this study, investigators aimed to investigate the role of matrix metalloproteinase enzymes in pulmonary arterial wall remodeling in patients with chronic thromboembolic pulmonary hypertension
Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery. Only 4% of patients with acute pulmonary embolism develop chronic thromboembolic pulmonary hypertension and acute pulmonary embolism or deep vein thrombosis is reported in the anamnesis of 75% of those with chronic thromboembolic disease. Therefore, the etiology of the disease is not clear. Altought many studies are done, especially the role of inflamation is emhasised underlie the disease.
Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling. The clot formed in chronic thromboembolic pulmonary hypertension does not melt and turns into a fibrous state, it occludes the pulmonary artery.In this study, investigators aimed to investigate the role of matrix metalloproteinase enzymes in pulmonary arterial wall remodeling in patients with chronic thromboembolic pulmonary hypertension.
Matrix metalloprotinase enzymes are known to play a role in atherosclerosis. This research will investigate whether there is atherosclerosis together with inflamattion in the background of chronic thromboembolic hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PATİENT GROUP(GROUP 1) | This group is the group that underwent pulmonary thromboendarterectomy due to chronic thromboembolic pulmonary hypertension.Sample was taken from the material extracted from this group during operation. |
| |
| CONTROL GROUP(GROUP 2) | This group is the group that underwent lobectomy or pneumonectomy for another reason that the pulmonary artery is not affected. Patients operated for a reason other than chronic thromboembolic pulmonary hypertension and samples were taken from the intact pulmonary artery of the removed lung. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| matrix metalloproteinase enzymes 2 and 9 | Other | concentration of matrix metalloproteinase 2 and 9 enzymes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of Matrix Metalloproteinase 2 and 9 Enzymes | Measurement the concentration of matrix metalloproteinase 2 and 9 enzymes by elisa and western blot techniques. | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Study population has chronic thromboembolic pulmonary hypertension and will be performed pulmonary thromboendarterectomy.
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| Name | Affiliation | Role |
|---|---|---|
| mehmet yanartas | kartal kosuyolu hıgh specıalty training and research hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kartal Kosuyolu High Speciality Training and Research Hospital | Istanbul | Eyalet/Yerleşke | 34800 | Turkey (Türkiye) |
The data used in the study will be kept closed to the use of other users.
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| ID | Title | Description |
|---|---|---|
| FG000 | PATİENT GROUP(GROUP 1) | This group is the group that underwent pulmonary thromboendarterectomy due to chronic thromboembolic pulmonary hypertension.Sample was taken from the material extracted from this group during operation. matrix metalloproteinase enzymes 2 and 9: concentration of matrix metalloproteinase 2 and 9 enzymes |
| FG001 | CONTROL GROUP(GROUP 2) | This group is the group that underwent lobectomy or pneumonectomy for another reason that the pulmonary artery is not affected. Patients operated for a reason other than chronic thromboembolic pulmonary hypertension and samples were taken from the intact pulmonary artery of the removed lung. matrix metalloproteinase enzymes 2 and 9: concentration of matrix metalloproteinase 2 and 9 enzymes |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | PATİENT GROUP(GROUP 1) | This group is the group that underwent pulmonary thromboendarterectomy due to chronic thromboembolic pulmonary hypertension.Sample was taken from the material extracted from this group during operation. matrix metalloproteinase enzymes 2 and 9: concentration of matrix metalloproteinase 2 and 9 enzymes |
| BG001 |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Concentration of Matrix Metalloproteinase 2 and 9 Enzymes | Measurement the concentration of matrix metalloproteinase 2 and 9 enzymes by elisa and western blot techniques. | Posted | Mean | Standard Deviation | ng/ml | 1 year |
|
Adverse events were not monitored/assessed
Adverse Events were not monitored/assessed.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | PATİENT GROUP(GROUP 1) | This group is the group that underwent pulmonary thromboendarterectomy due to chronic thromboembolic pulmonary hypertension.Sample was taken from the material extracted from this group during operation. matrix metalloproteinase enzymes 2 and 9: concentration of matrix metalloproteinase 2 and 9 enzymes |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr.Ahmet Zengin | Kartal Kosuyolu Hihg Speciality Training and Research Hospital | +905365022173 | dr.zenginahmet@gmail.com |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Mar 3, 2020 | Jul 8, 2021 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Mar 3, 2020 | Jul 8, 2021 | SAP_001.pdf |
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Samples was teken from pulmonary endarterectomy material during the operation. This material is removed routinly this surgical procedure. At this studt any extra surgical procedure did not performed to participans.
| CONTROL GROUP(GROUP 2) |
This group is the group that underwent lobectomy or pneumonectomy for another reason that the pulmonary artery is not affected. Patients operated for a reason other than chronic thromboembolic pulmonary hypertension and samples were taken from the intact pulmonary artery of the removed lung. matrix metalloproteinase enzymes 2 and 9: concentration of matrix metalloproteinase 2 and 9 enzymes |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| height | Mean | Standard Deviation | cm |
|
| Weight | Mean | Standard Deviation | kg |
|
|
|
|
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | CONTROL GROUP(GROUP 2) | This group is the group that underwent lobectomy or pneumonectomy for another reason that the pulmonary artery is not affected. Patients operated for a reason other than chronic thromboembolic pulmonary hypertension and samples were taken from the intact pulmonary artery of the removed lung. matrix metalloproteinase enzymes 2 and 9: concentration of matrix metalloproteinase 2 and 9 enzymes | 0 | 0 | 0 | 0 | 0 | 0 |
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