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| ID | Type | Description | Link |
|---|---|---|---|
| 31-8-2010 | Other Identifier | AristotleU |
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| Name | Class |
|---|---|
| AHEPA University Hospital | OTHER |
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The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.
The purpose of this study is to determine the correlation of matrix metalloproteinases and atherosclerosis of chronic kidney disease. Patients with diabetes mellitus type 2,as a non-inflammatory leading cause of end stage renal failure and patients with chronic glomerulonephritis and similar course of proteinuria,as an inflammatory leading cause of end stage renal failure are enrolled.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diabetic nephropathy | Diabetic nephropathy in patients with type 2 diabetes | ||
| chronic glomerulonephritis | chronic glomerulonephritis in patients without diabetes mellitus | ||
| controls | participants without diabetic nephropathy and chronic glomerulonephritis |
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| Measure | Description | Time Frame |
|---|---|---|
| Association of matrix metalloproteinases with atherosclerosis in patients with chronic kidney disease | Matrix metalloproteinases associated with atherosclerosis in chronic kidney disease;patients with diabetes mellitus type 2 and others with chronic glomerulonephritis.Serum levels of MMPs-2 and -9 are measured by an ELISA system.Intima Media Thickness(IMT) of carotid and femoral arteries is measured with a high resolution ultrasonography. | two years |
| Measure | Description | Time Frame |
|---|---|---|
| Matrix metalloproteinases and atherosclerosis associated with pro-inflammatory and oxidative stress markers in chronic kidney disease | Matrix metalloproteinases associated with atherosclerosis markers,pro-inflammatory markers and markers of oxidative stress in chronic kidney disease | two years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from University Hospital AHEPA
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Grigorios G. Dimas | Contact | +0030 6972321534 | gregorydimas@yahoo.gr |
| Name | Affiliation | Role |
|---|---|---|
| Grigorios G. Dimas, MD | AHEPA University Hospital,Medical School of Aristotle University of Thessaloniki | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AHEPA University Hospital, Medical School of Aristotle University of Thessaloniki | Recruiting | Thessaloniki | Greece |
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| ID | Term |
|---|---|
| D003928 | Diabetic Nephropathies |
| D007674 | Kidney Diseases |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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serum and vessels
| D052801 | Male Urogenital Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |