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The purpose of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery
Background and objectives: morbidly obese patients are characterized by a high prevalence of restrictive lung disease. Respiratory mechanics are significantly altered in obesity. These changes are exacerbated with general anesthesia .Obesity also results in reduced lung and chest wall compliance ,increased lung resistance ,reduced oxygenation.MgSo4 is promising in managing several respiratory disorders.it cause smooth muscle relaxation and reduce airflow obstruction.
The objective of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery.
the following will be recorded :intraoperative oxygenation,lung mechanics,MAP,HR,EtCO2,plateau and peak airway pressure,sedation score,serum mgso4 level,change in P/F ratio and dynamic lung compliance,respiratory rate postoperative
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| M group (Mg sulphate ) | Active Comparator | patients will receive 30mg/kg LBW of 10%mgso4 in 100 ml normal saline intravenously over 30 minutes as a loading dose ,followed by 10 mg /kg LBW for 90 minutes |
|
| C group (control ) | No Intervention | patients will receive 100 ml of normal saline intravenously over 30 minutes followed by saline infusion for 90 minutes |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mg sulphate | Drug | mgso4 infusion will start 15 minutes after intubation , 30 mg/kg LBW of 10%mgso4 in 100 ml normal saline I.V ,over 30 minutes followed by 10 mg/kg LBW for 90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Pao2 | arterial oxygenation during surgery determined by Pao2 | 5 minutes after intubation to 90 minutes after starting drug infusion |
| Pao2/FIO2 | arterial oxygenation during surgery determined by Pao2/FIO2 | 5 minutes after intubation to 90 minutes after starting drug infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Static lung compliance | will be calculated as:tidal volume/(plateau pressure-positive end expiratory pressure) | 5 minutes after intubation to 90 minutes after starting drug infusion |
| mg sulphate level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marwa M Mowafi, MD | Ain Shams University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University Hospital | Cairo | Abassia | 11591 | Egypt |
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| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
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|
serum mgso4 level
| One hour postoperatively |
| dead space | dead space will be calculated as : Vd/Vt | 5 minutes after intubation to 90 minutes after starting drug infusion |
| Dynamic lung compliance | will be calculated as :tidal volume/(peak airway pressure-positive end expiratory pressure) | 5 minutes after intubation to 90 minutes after starting drug infusion |
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |