Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation

Effects of Magnesium Sulfate on Intraoperative Oxygenation and Lung Mechanics During One-Lung Ventilation: A Prospective Observational Study

This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation.

In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.

Inclusion Criteria:

Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia.

ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement

Exclusion Criteria:

• Patients undergoing pneumonectomy
• Patients with renal, hepatic, or cardiovascular failure
• Patients with a BMI < 15 kg/m² or > 35 kg/m²
• Patients with a preoperative pulmonary function test showing FEV₁ < 1.5 liters
• Patients who are transferred to the intensive care unit intubated in the postoperative period
• Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors