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The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients | Consenting patients undergoing non-emergency surgery with anesthesia |
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| Measure | Description | Time Frame |
|---|---|---|
| Assessing the change of the metabolic profile in the perioperative setting | Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome. | Before induction of anesthesia as baseline |
| Assessing the change of the metabolic profile in the perioperative setting | Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome. | Ca. 2-5hours later upon finishing the surgery |
| Assessing the change of the metabolic profile in the perioperative setting | Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome. | On postoperative day 1 during the morning round between 07:30-9:00am |
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Inclusion Criteria:
Exclusion Criteria
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Patients scheduled for non-emergency surgery
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| Name | Affiliation | Role |
|---|---|---|
| Frank Stüber, Prof. MD | Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern | Study Chair |
| Markus M Lüdi, MD | Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern | Bern | 3010 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38379859 | Derived | Bello C, Filipovic MG, Huber M, Flannery S, Kobel B, Fischer R, Kessler BM, Raber L, Stueber F, Luedi MM. Discovery of plasma proteome markers associated with clinical outcome and immunological stress after cardiac surgery. Front Cardiovasc Med. 2023 Dec 22;10:1287724. doi: 10.3389/fcvm.2023.1287724. eCollection 2023. | |
| 34831051 |
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Whole blood (plasma and cells)
| Heinisch PP, Mihalj M, Huber M, Schefold JC, Hartmann A, Walter M, Steinhagen-Thiessen E, Schmidli J, Stuber F, Raber L, Luedi MM. Impact of Lipoprotein(a) Levels on Perioperative Outcomes in Cardiac Surgery. Cells. 2021 Oct 21;10(11):2829. doi: 10.3390/cells10112829. |