Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Prospective association study to analyse perioperative patients' outcome. Outcome comprises intraoperative and postoperative complications e.g. cardio-vascular events, allergic reactions, Possible variables which might have on influence: patient- and surgery-related data, patients' genetic background etc.
Background Anesthesia and surgery are related to unwanted adverse events, side effects and postoperative discomfort. Whereas severe complications like cardiovascular events are rare, postoperative side effects like nausea and vomiting, pain, long-lasting pain and pain related interference of daily activities are frequent. The question arises which patient is at specific risk for this sequelae. Pre-exiting predisposing factors (e.g. patients' genetic background), surgery and anesthesia related variables (drugs, techniques administered for anesthesia and analgesia) as well as psychological and social factors might influence the outcome.
In this prospective association study these variables will be investigated in a well-described patient cohort presenting for elective surgery.
Objective
The aim of this study is to associate perioperative and postoperative complications and side effects as well as long-term outcome after surgery to patient- and surgery-related variables, including genetic variants.
Methods
Prospective association study performed in two independent patient cohorts.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients | Patients undergoing elective surgery with anesthesia |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative nausea and vomiting (PONV) | Percent of patients with no PONV, medium PONV and severe PONV PONV outcome measured by a composite score: number of episodes of vomiting + severity of nausea (NRS score) + need for antiemetic treatment Patients with no PONV are compared to those with intermediate and severe PONV | Up to 48 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Pain related impairment after surgery | Measured by the International Pain Outcomes Questionnaire | up to 2 days after surgery |
| Pain related impairment of patients with chronic pain after surgery versus patients without chronic pain after surgery |
Not provided
Inclusion Criteria:
Exclusion Criteria
Not provided
Not provided
Not provided
Patients scheduled for elective surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ulrike M Stamer, Prof. MD | Contact | 0041-316329995 | ulrike.stamer@dbmr.unibe.ch | |
| Markus Lüdi, MD | Contact | 0041-316323965 | markus.luedi2@insel.ch |
| Name | Affiliation | Role |
|---|---|---|
| Frank Stüber, Prof. MD | Department of Anaestheisolpogy + Pain Medicine, Inselspital, University of Bern | Study Chair |
| Ulrike M Stamer, MD | Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern | Recruiting | Bern | 3010 | Switzerland |
Not provided
| ID | Term |
|---|---|
| D000377 | Agnosia |
| D011183 | Postoperative Complications |
| D010146 | Pain |
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
whole blood (plasma and cells) or mucosal swab
Measured by the Brief Pain Inventory (BPI)
| up to one year after surgery |
| Cardio-vascular events after surgery | Measured by a score for major adverse cardiac events (MACE) | Up to 30 days after surgery |
| Pain related impairment of patients with chronic neuropathic pain (DN4 positive) after surgery versus patients without neuropathic pain after surgery | Measured by the Brief Pain Inventory (BPI) | up to one year after surgery |
| What influences pain related impairment after bariatric surgery | Measurement of patient reported outcome by the BPI (Brief Pain Inventory). | up to 1 year after surgery |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
| D009325 | Nausea |
| D012817 | Signs and Symptoms, Digestive |
| D014839 | Vomiting |